Cell Lines and Cell Cultures
Thermo Scientific™ GeneBLAzer™ Bradykinin-B2-NFAT-bla CHO-K1 Cells
GeneBLAzer™ Bradykinin-B2-NFAT-bla CHO-K1 cells contain the human Bradykinin Receptor B2 (B2) stably integrated into the CellSensor™ CRE-bla CHO-K1 cell line.
Thermo Scientific™ Tango™ ADRA2A-bla U2OS Cells
The Tango™ ADRA2A-bla U2OS cells contain the human Adrenergic, Alpha-2A-, Receptor (ADRA2A) linked to a TEV protease site and a Gal4-VP16 transcription factor stably integrated into the Tango™ GPCR-bla U2OS parental cell line.
Thermo Scientific™ GeneBLAzer™ RARα-UAS-bla HEK 293T Cells
RAR alpha-UAS-bla HEK 293T cells contain the ligand-binding domain (LBD) of the human retinoic acid receptor alpha fused to the DNA-binding domain of GAL4 stably integrated in the GeneBLAzer™UAS-bla HEK293T cell line.
Thermo Scientific™ CellSensor™ LEF/TCF-bla HCT-116 Cell Line
Wnt signaling via Beta-catenin plays a central role in development and homeostasis. This pathway is invariably disrupted in colorectal tumors and commonly affected by mutation in other cancers.
Thermo Scientific™ CellSensor™ AP-1-bla HEK293T Cell Line
The CellSensor™ AP-1-bla HEK 293T Cell Line contains a beta-lactamase reporter gene under control of the AP-1 response element stably integrated into HEK 293T cells.
Thermo Scientific™ GeneBLAzer™ OPRK1-Gqo5-NFAT-bla CHO-K1 Cells
The GeneBLAzer™ OPRK-1-Gqo5-NFAT-bla CHO-K1 cells contain the human Opioid Receptor Kappa 1 (OPRK1) (Accession No. NM_000710) stably integrated into the GeneBLAzer™ Gqo5-NFAT-bla CHO-K1 cell line.
GeneBLAzer™ GCGR-CRE-bla CHO-K1 Cells
GeneBLAzer™ GCGR-CRE-bla CHO-K1 Cells contain the human glucagon receptor (GCGR).
Thermo Scientific™ GeneBLAzer™ CALCRL:RAMP1-CRE-bla FreeStyle™ 293F Cells
GeneBLAzer™ CALCRL:RAMP1-CRE-bla FreeStyle™ 293F cells contain the human Calcitonin Gene Related Peptide Receptor (CALCRL:RAMP1), stably integrated into the CellSensor™ CRE-bla Freestyle™ 293F cell line.
Thermo Scientific™ CellSensor™ SBE-bla A375 Cell Line
Bone morphogenetic proteins (BMPs), members of the transforming growth factor beta (TGF-β) superfamily, play important roles in the development of the heart, central nervous system and cartilage.
Thermo Scientific™ CellSensor™ ESRE-bla HeLa Cell Line
Endoplasmic Reticulum (ER) stress is associated with a variety of pathophysiological conditions, such as neurodegenerative diseases, diabetes, tumor growth under hypoxic conditions, and ischemic heart disease.
Thermo Scientific™ LanthaScreen™ ERK2 U2OS Cell Line
The Map Kinase (MapK) signal transduction cascade is activated by growth factors such as EGF, PDGF, and HGF. Binding of these factors to their respective cell surface receptors results in the initiation of receptor tyrosine kinase activity.
Thermo Scientific™ LanthaScreen™ c-Jun (1-79) HeLa Cell Line
The LanthaScreen™ c-Jun (1-79) HeLa cell line contains a fusion protein consisting of GFP and a fragment encoding for AA 1-79 of c-Jun under the control of a CMV promoter stably transfected into HeLa cell lines.
Thermo Scientific™ CellSensor™ NFkB-bla RAW 264.7 Cell Line
The CellSensor™ NFκB-bla RAW264.7 mouse macrophage cell line contains a beta-lactamase reporter gene under control of a stably integrated NFκB response element.
Thermo Scientific™ CellSensor™ ISRE-bla HEK293T Cell Line
The CellSensor™ ISRE-bla HEK 293T cell line is responsive to interferon alpha and can be used to probe the JAK/STAT signaling pathway.
Thermo Scientific™ GeneBLAzer™ ADRB2-CRE-bla CHO-K1 Cells
The GeneBLAzer™ ADRB2-CRE-bla CHO-K1 cells contain the human Adrenergic Beta-2 Receptor (ADRB2), (Accession No. NM_000024.3) stably integrated into the CellSensor™ CRE-bla CHO-K1 cell line.